Painless gastroenteroscopy
Conditions
Interventions
Alfentanil plus propofol group (AP group):Alfentanil 7 µg/kg, propofol 2 mg/kg
Alfentanil combined with Remazolam besylate group (AR group):Alfentanil 7 µg/kg, remazolam besylate 0.2 mg/kg
Sufentanil plus Remazolam besylate group (SR group):Sufentanil 0.1 µg/kg, remazolam besylate 0.2 mg/kg
Sponsors
People’s Hospital of Lishui
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Patients who met all of the following criteria were considered for enrollment: 1) Patients undergoing elective painless gastroscopy and colonoscopy; 2) Age 18-60, both sexes; 3) Body mass index (BMI): 18.5-28 kg/m2; 4) American Society of Anesthesiologists Classification (ASA): I~II; 5) Operation time within 45 min; 6)Subjects voluntarily participated in the study and signed the informed consent form for the study.
Exclusion criteria
Exclusion criteria: Patients who met any of the following criteria were not eligible for inclusion: 1) The subject explicitly refuses to participate in this study; 2) Allergic to opioids, benzodiazepines, propofol, flumazenil or naloxone excipients; 3) Use of beta-blockers, anti-anxiety drugs and antidepressants; 4) Suspected abuse of narcotic analgesics or sedatives, as well as alcoholics; 5) Electrocardiogram prompts: heart rate 100 beats /min or severe arrhythmia; 6) A history of acute respiratory tract infection within 2 weeks without cure; 7) Patients with a history of severe heart, brain, lung, liver, kidney or metabolic diseases, neuromuscular system diseases (such as myasthenia gravis), mental diseases; 8) Preoperative systolic blood pressure >180 mmHg and/or diastolic blood pressure >110 mmHg in hypertensive patients, or <90/60 mmHg in hypotensive patients; 9) Patients with previous history of gastrointestinal diversion; 10) Patients with previous abnormal surgical anesthesia recovery history; 11) Those who are predicted to have or have had difficult airway, such as modified Mahalanobis grade III-IV; 12) Pregnant or lactating women and patients (including men) who plan to have children within 3 months 13) Other subjects deemed inappropriate by other investigators to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of intraoperative respiratory depression; | — |
Secondary
| Measure | Time frame |
|---|---|
| effectiveness index;safety index;Satisfaction score; | — |
Countries
China
Contacts
Public ContactJimin WU
People’s Hospital of Lishui
Outcome results
None listed