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Efficacy and Safety of Intravitreal Conbercept with Modified Treat-and-Extend Regimens in Exudative Age-Related Macular Degeneration: 1 year Findings

Efficacy and Safety of Intravitreal Conbercept with Modified Treat-and-Extend Regimens in Exudative Age-Related Macular Degeneration: 1 year Findings

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200065000
Enrollment
Unknown
Registered
2022-10-25
Start date
2018-11-16
Completion date
Unknown
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

wet age-related macular degeneration

Interventions

group 1:Drug injection adjustment interval is 2 weeks
group 2:Drug injection adjustment interval is 4 weeks

Sponsors

The First Affiliated Hospital of Chongqing Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
55 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1. Age >= 50 years and meeting the diagnostic criteria for wet AMD; 2. OCTA suggesting the presence of subretinal neovascularization; 3. No prior treatment (anti-VEGF, PDT, etc.); 4. Best-corrected visual acuity (BCVA) between 5-75 letters in the study eye.

Exclusion criteria

Exclusion criteria: 1. Allergy to drugs needed in the diagnosis and treatment; 2. A history of internal eye surgery (except surgery about cataract), trauma or fundus laser photocoagulation; 3. Other ophthalmologic diseases besides wAMD or cataracts; 4. Renal insufficiency and serious cardiovascular and cerebrovascular diseases; 5. Surgery required due to vitreous hemorrhage during follow-up treatment; 6. Recent preparation for childbirth, pregnancy or lactation; 7. Poor compliance with diagnosis and treatment or difficulty conducting regular outpatient review and cooperating with treatment.

Design outcomes

Secondary

MeasureTime frame
central retinal thickness;last injection interval;number of injections;

Primary

MeasureTime frame
The best-corrected visual acuity;

Countries

China

Contacts

Public ContactHui Peng

The First Affiliated Hospital of Chongqing Medical University

pengh9@sina.com+86 13072369950

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026