Hypertension in the elderly patients
Conditions
Interventions
group 2:Low-dose remimazolam tosylate for injection
group 3:High dose remimazolam tosylate for injection
Sponsors
Affiliated Hospital of Guizhou Medical University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Elderly hypertensive patients who plan to undergo elective non-cardiac surgery; 2. Age > 65 years old, ASA I-? level; 3. Clearly understand and voluntarily participate in the study, and the informed consent is signed by himself or his family members.
Exclusion criteria
Exclusion criteria: 1. Patients who are allergic to benzodiazepines, etomidate, opioids and their ingredients or have contraindications; 2. Patients with obvious respiratory dysfunction before operation (obstructive sleep apnea syndrome, acute respiratory infection, acute exacerbation of chronic obstructive pulmonary disease, uncontrolled asthma, etc.); 3. Those with preoperative circulatory dysfunction (unstable angina pectoris; myocardial infarction within 6 months before screening; resting ECG heart rate = 450 ms, female >= 470 ms); 4. Anemia or thrombocytopenia: Hb < 90 g/L, PLT < 80 × 10^9/L; 5. Suffering from psychiatric diseases (schizophrenia, mania, bipolar disorder, insanity, etc.) and long-term history of taking psychotropic drugs and cognitive dysfunction; 6. Patients who are judged to have difficulties in airway management: modified Matheson score grade III and above; 7. Patients who are participating in other clinical trials; 8. The investigator thinks that it is not suitable to participate in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MAP change value during induction of general anesthesia;HR change value during induction of general anesthesia;Incidence of cardiovascular adverse events; | — |
Secondary
| Measure | Time frame |
|---|---|
| Use of vasoactive drugs;Postoperative cognitive function; | — |
Countries
China
Contacts
Public ContactZou Xiaohua
Affiliated Hospital of Guizhou Medical University
Outcome results
None listed