Rheumatoid arthritis
Conditions
Interventions
Experiment group:Type II resistant starch
Control group:common starch
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
25 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Age >= 30 to = 1 joint swelling and/or pain, with or without morning stiffness) and duration >= 2 weeks; 4. The patient had no previous history of rheumatic diseases, such as rheumatoid arthritis, systemic lupus erythematosus, etc. 5. The patient had not used anti-rheumatic drugs (DMARDs, including biological agents) to improve the condition; 6. Patients have not used glucocorticoids; 7. Patients who did not participate in any drug trial within 3 months before enrollment; 8. Patients voluntarily participated in the trial, had good compliance and were able to understand and sign informed consent before the study.
Exclusion criteria
Exclusion criteria: 1. Pregnant women, women preparing for pregnancy or lactation; 2. Patients with a history of chronic diarrhea or peptic ulcer in the past 1 year; 3. People with mental disorders, a history of alcoholism, drug or other substance abuse; 4. Joint symptoms are caused by other known causes (including but not limited to osteoarthritis, gout, infection, etc.); 5. Patients with malignant tumors; 6. Allergic or contraindicated to test drugs; 7. There are various other cases in which investigators consider it impossible to join the clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in the proportion of patients diagnosed with RA according to the revised (2010) ACR after treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| The total number of tender joints (TJC) and the total number of swollen joints (SJC) in the total number of 28 joints were changed;Changes of serum anti-cyclic citrulline antibody (ACPAs) levels;Changes of serum inflammatory response protein (CRP, ESR) level;Changes of intestinal flora and fecal metabolome; | — |
Countries
China
Contacts
Public ContactLiu Yi
West China Hospital of Sichuan University
Outcome results
None listed