Sepsis
Conditions
Interventions
Group 1:oxygen therapy (PaO2 and SpO2 targets 80-100 mmHg and 95-97%)
Group 2:oxygen therapy (PaO2 and SpO2 target 60mmHg <= PaO2 < 80 mmHg and SpO2 88-94%)
Group 3:oxygen therapy (The target of PaO2 and SpO2 is 100mmHg < PaO2 < 150 mmHg, SpO2 98-100%)
Sponsors
Beijing Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years old; 2. Diagnosed with sepsis or septic shock according to the 2016 sepsis definition 3.0, with an expected hospital stay of more than 48 hours; 3. Sign the informed consent form to participate in this study voluntarily.
Exclusion criteria
Exclusion criteria: 1. Patients after elective surgery; 2. Patients diagnosed with severe acute respiratory distress syndrome (ARDS) according to the Berlin criteria, who do not agree to invasive mechanical ventilation or who cannot achieve the expected oxygenation target after using invasive mechanical ventilation to meet preset support conditions; 3. Pregnancy; 4. Severe chronic obstructive pulmonary disease (Global Chronic Obstructive Pulmonary Disease Initiative III/IV level); 5. Those whose condition requires invasive ventilation but who sign and refuse invasive rescue; 6. Carbon monoxide or cyanide poisoning or methemoglobinemia; 7. Sickle cell disease or known past abnormalities in the number and function of red blood cells; 8. Known right-to-left shunt of the heart; 9. Known new cerebral hemorrhage or cerebral infarction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Survival or death;MRS neurological outcome score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Artery blood gas;Oxygen saturation;Cerebral oxygen saturation;Tissue oxygen saturation;Clinical parameters of SOFA score; | — |
Countries
China
Contacts
Public ContactChen Xi
Beijing Hospital
Outcome results
None listed