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The association between the compositional changes of gut microbiota and steroid dependence in children with primary nephrotic syndrome

The association between the compositional changes of gut microbiota and steroid dependence in children with primary nephrotic syndrome

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2200064933
Enrollment
Unknown
Registered
2022-10-24
Start date
2017-09-28
Completion date
Unknown
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Primary nephrotic syndrome

Interventions

Group 1:
Group 2:
Group 3:

Sponsors

Shanghai Children's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Normal children, children with primary nephrotic syndrome, regardless of gender.

Exclusion criteria

Exclusion criteria: 1. PNS patients with other organ diseases; 2. Abnormal renal function (eGFR < 90 ml/min.1.73m^2); 3. A history of gastrointestinal surgery, receivedantibiotic, probiotics and immunosuppressant treatmentin the previous 2 months.

Design outcomes

Primary

MeasureTime frame
Gut microbiota;—

Secondary

MeasureTime frame
Recurrence times;Short chain fatty acids;Cytokines;Cellular immunity;Serum albumin;Serum creatinine;24h urinary protein;24h urinary protein;—

Countries

China

Contacts

Public ContactKang Yulin

Department of Nephrology and Rheumatology, Shanghai Children's Hospital

kangyulinmed@126.com+86 18221992381

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026