cervical cancer
Conditions
Interventions
Group 2:No
Group 5:oral probiotics
Group 6:Vaginal Medicated Probiotics
Group 7:Oral + Vaginal Medicated Probiotics
Group 8:placebo
Sponsors
Guangzhou Eighth People's Hospital, Guangzhou Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-50 years old, women undergoing HPV examination; 2. People with sexual life history, non-menopausal or non-pregnant; 3. No sexual life, vaginal medication, and washing within 3 days before sampling; 4. Patients who need surgical resection of part or all of the cervical tissue due to cervical lesions or other reasons.
Exclusion criteria
Exclusion criteria: 1. Within 8 weeks of pregnancy or postpartum; 2. Those with a history of reproductive tract tumors; 3. HPV vaccination history, including bivalent, quadrivalent, and nine-valent; 4. Previous history of hysterectomy, cervical surgery, and pelvic radiation therapy; 5. Received treatment related to reproductive tract infection, HPV or other STDs pathogen infection in the past 3 months; 6. Use of broad-spectrum antibiotics or topical probiotics or vaginal suppositories in the reproductive tract in the past 1 month; 7. Drug abuse, mental disorder, incomplete information; 8. Exclude patients with other immunodeficiency diseases other than HIV infection or long-term use of immunosuppressants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 16S rDNA Amplicon Sequencing; | — |
Secondary
| Measure | Time frame |
|---|---|
| HPV test;cervical liquid-based cytology;Cervical histopathology;transcriptome sequencing;Metabolomics testing; | — |
Countries
China
Contacts
Public ContactHuichao Liang
Guangzhou Eighth People's Hospital, Guangzhou Medical University
Outcome results
None listed