procedural sedation for gastrointestinal endoscopy
Conditions
Interventions
Group 1:a bolus cyprofol of 0.8 mg/kg
Group 2:a combination of intravenous 0.75 mg/kg cyprofol and 0.25 ug/kg fentanyl
Group 3:a combination of intravenous 0.7 mg/kg cyprofol and 0.5ug/kg fentanyl
Group 4:a combination of intravenous 0.65 mg/kg cyprofol and 0.75ug/kg fentanyl
Group 5:a combination of intravenous 0.6 mg/kg cyprofol and 1ug/kg fentanyl
Sponsors
Department of Anesthesiology, Shanghai Childre's Medical Center Affiliated to School of Medicine, Shanghai Jiao Tong University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Pediatric patients aged 3-12 years, with ASA I-III, who were scheduled for elective gastrointestinal endoscopy.
Exclusion criteria
Exclusion criteria: Weight less than 10 kg, severe gastroesophageal reflux disease and other risk of vomiting, oral sedative drugs used within 24 hours, active gastric bleeding, obesity (BMI > 35 kg/m2), mental or neurological diseases, presence of Liver, kidney and other important organs were damaged and there was allergy to propofol in the past.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 90% Effective Dose of Cyprofol; | — |
Secondary
| Measure | Time frame |
|---|---|
| procedural tolerance using a 10-point visual analog scale;the lowest value of BIS;mean blood pressure;heart rate;periepheric oxygen saturation;numbers and times of BIS < 40;recovery time;postoperative emergence and delirium assessment using PAEDS scale;pain assessment using FLACC scale score in the PACU; | — |
Countries
China
Contacts
Public ContactZheng Jijian
Shanghai Children's Medical Center Affiliated to School of Medicine, Shanghai Jiao Tong University
Outcome results
None listed