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Clinical study on improvement of halitosis by Lactobacillus paracasei ET22

Clinical study on improvement of halitosis by Lactobacillus paracasei ET22

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200064913
Enrollment
Unknown
Registered
2022-10-21
Start date
2022-11-10
Completion date
Unknown
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Halitosis

Interventions

Group 1 :no intervention
Group 2:ET22 live bacteria intervention
Group 3:ET22 heat-killed bacteria intervention

Sponsors

China Agricultural University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1. Subjects without caries, periodontitis and other oral diseases; 2. No systemic disease; 3. Age 20-45 years old; 4. Subjects without any history of preventive dental treatment; 5. Halimeter detector index >= 120.

Exclusion criteria

Exclusion criteria: 1. Subjects who received antibiotics during the study; 2. Subjects using any other probiotic supplements (yogurt or other supplements containing probiotics) during the study; 3. Subjects using xylitol products 1 week before the start of the experiment and during the study; 4. Subjects with a history of intraoral surgery within 6 months before the start of the experiment; 5. Subjects with systemic diseases (gastritis, etc.) that cause halitosis; 6. Current smokers or smokers one year before the start of the experiment.

Design outcomes

Primary

MeasureTime frame
salivary flora;Halimeter detector indicators;

Countries

China

Contacts

Public ContactWang Ran

China Agricultural University

wangran8609@126.com+86 13811855282

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026