Clinical study of early cleavage stage embryo fragmentation observation combined with low oxygen concentration culture to improve early embryonic development

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200064870

Enrollment

Unknown

Registered

2022-10-20

Start date

2022-10-20

Completion date

Unknown

Last updated

2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

infertility

Interventions

Intervention group:hypoxic culture

Control group:none

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. Observe early cleavage 25-27 hours after insemination, the fragmentation rate is greater than 50% of the number of cleavage; 2. 25-27 hours observe early cleavage fragmentation embryo incidence rate <25%, D2 has 50% eggs fragmentation of fission-stage embryos was greater than 15%.

Exclusion criteria

Exclusion criteria: 1. Chromosomal abnormality in either male or female; 2. Obvious egg maturation and abnormal morphological structure in the past; 3. Remedial ICSI cycle.

Design outcomes

Primary

Measure	Time frame
Grading of D3 embryos;D5 blastocyst shape;	—

Countries

China

Contacts

Public ContactXu Weihai

Zhejiang Provincial People's Hospital

xuweihai@hmc.edu.cn+86 13588706942

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026