Postoperative pain
Conditions
Interventions
Group A:0.02% hydromorphone hydrochloride 0.2 mg gelatin sponge was aspirated by epidural indwelling
Group B:0.02% hydromorphone hydrochloride 0.3 mg gelatin sponge was aspirated by epidural indwelling
Group C:0.02% hydromorphone hydrochloride 0.4 mg gelatin sponge was aspirated by epidural indwelling
Sponsors
Ganzhou People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 76 Years
Inclusion criteria
Inclusion criteria: 1. ASA grade I-II; 2. Patients were in good mental state and had no communication disorder, the inflammatory reaction was controlled before operation; 3. Patients and their family members voluntarily signed the informed consent; 4. No history of allergic reaction to opioids or nsaids, and no long-term use of central nervous system; 5. The basic diseases were controlled in acceptable level, no alcohol abuse, no visual or hearing impairment; 6. The range of operation was 1-2 vertebrae.
Exclusion criteria
Exclusion criteria: 1. Complicated with mental disorders and use of psychotropic drugs; 2. Preoperative CAM score >=20; 3. Long-term use of analgesic drugs; 4. Combined with immune, blood and endocrine system diseases; 5. Patients had infectious diseases before operation; 6. Severe heart, liver and kidney dysfunction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual analogue scale (VAS) pain score;Serum levels of C-reactive protein (CPR) , interleukin-6(IL-6) and tumor necrosis factor (TNF-a) ;Patient cognitive function; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse reaction;Hemodynamics; | — |
Countries
China
Contacts
Public ContactDeng Ruiming
Ganzhou People's Hospital
Outcome results
None listed