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Effects of esketamine pretreatment on intestinal injury and intestinal microflora in patients undergoing gynecological laparoscopic surgery

Effects of esketamine pretreatment on intestinal injury and intestinal microflora in patients undergoing gynecological laparoscopic surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200064841
Enrollment
Unknown
Registered
2022-10-19
Start date
2022-10-14
Completion date
Unknown
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

The esketamine group:None

Sponsors

Affiliated Hospital of Southwest Medical University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
30 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. ASA grading ?-?; 2. Aged between 30 and 60 years; 3. BMI18-25kg/m^2; 4. Preoperative hematuria routine, blood cell analysis, biochemistry, electrolyte and coagulation tests showed no obvious abnormalities; 5. Electrocardiogram and chest radiograph showed no obvious abnormality.

Exclusion criteria

Exclusion criteria: 1. During the operation, the patient was transferred to open the abdomen due to the condition; 2. The patient is allergic to esketamine; 3. Have confirmed gastrointestinal disease or obvious symptoms of gastrointestinal discomfort; 4. Disagree with participants.

Design outcomes

Primary

MeasureTime frame
Intestinal fatty acid binding protein;—

Secondary

MeasureTime frame
Diamine oxidase;D-lactic acid;IL-6;Tumor necrosis factor;Superoxide dismutase;Malondialdehyde;—

Countries

China

Contacts

Public ContactZhou Jun

Affiliated Hospital of Southwest Medical University

47147381@qq.com+86 18715816677

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026