To explore the molecular mechanism of Lingzhu granule in the treatment of phlegm dampness polycystic ovary syndrome based on the change of microbial flora

Analysis of microbiological characteristics of intestinal tract and tongue coating in patients with polycystic ovary syndrome

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2200064835

Enrollment

Unknown

Registered

2022-10-19

Start date

2022-10-19

Completion date

Unknown

Last updated

2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Polycystic ovary syndrome (PCOS)

Interventions

Phlegm-dampness PCOS patients group:None

Non-phlegm-dampness PCOS group:None

Healthy subjects group:None

Eligibility

Sex/Gender

Female

Age

18 Years to 35 Years

Inclusion criteria

Inclusion criteria: 1. Female aged 18-35 years with normal liver and kidney function; 2. Meet the diagnostic criteria of PCOS Rotterdam; 3. Meet the diagnostic criteria of phlegm-dampness syndrome of traditional Chinese medicine.

Exclusion criteria

Exclusion criteria: 1. Antibiotics and other drugs used in the last 1 month, oral contraceptives, glucocorticoid, antiandrogen drugs, ovulation promoting drugs, diabetes drugs or other steroid drugs taken within 3 months; 2. Fever, gastrointestinal disease, and active infection occurred during sampling; 3. Patients with hyperprolactinemia, hypothyroidism or hyperthyroidism, complicated with serious disorders of liver, kidney, hematopoietic system, infectious diseases or mental disorders, hypertension or diabetes; 4. Pregnant or lactating patients.

Design outcomes

Primary

Measure	Time frame
Microbial composition of the digestive tract;Fecal microorganisms;	—

Secondary

Measure	Time frame
Objectify tongue image parameters;TCM syndrome scale;Body mass index;Waist circumference;Hip circumference;Biochemical indicators;	—

Countries

China

Contacts

Public ContactXu Min

Guangdong Hospital of Traditional Chinese Medicine

Xumin3333@163.com+86 13922310114

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026