None listed
Conditions
Interventions
Group H:use protective lung ventilation strategies during surgery to maintain end-tidal carbon dioxide partial pressure at 50-65mmHg
Group L:do not use protective lung ventilation strategies during surgery to maintain end-tidal carbon dioxide partial pressure at 35-45mmHg
Sponsors
Department of Anesthesiology, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
65 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Aged >= 65 years; 2. Plan for thoracoscopic lung surgery under general anesthesia; 3. Plan for intraoperative one-lung ventilation; 4. Previous cerebral infarction, luminal infarction, TIA, carotid artery stenosis or plaque that affects the blood supply to the brain; 5. Plan for anatomic lung resection; 6. Agree to participate and sign written informed consent.
Exclusion criteria
Exclusion criteria: 1. Severe lung dysfunction (including pneumonia, atelectasis, pleural effusion, acute lung injury, ARDS); 2. Severe renal insufficiency (preoperative renal replacement therapy); 3. Severe circulatory instability (severe coronary artery disease, unstable angina pectoris, left ventricular ejection fraction < 30%, sick sinus syndrome, severe sinus bradycardia <50 bpm, second degree or more severe atrioventricular block); 4. Diabetic patients; 5. Participate in other clinical trials within 30 days prior to randomization; 6. The responsible physician or endoscopist or anesthesiologist suggested other reasons for not participating in the experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cerebral desaturation (bilateral rSO2 reduction to 90% of baseline) event rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cerebral oxygen saturation;Vasoactive drug use rate;Extubation time;Wake up time;Wake time;Incidence of agitation during recovery;PACU stay time;Incidence of nausea and vomiting 24 hours after operation;Incidence of delirium 24 hours after surgery; | — |
Countries
China
Contacts
Public ContactWu Jingxiang
Department of Anesthesiology, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed