Postmenopausal osteoporosis
Conditions
Interventions
Experimental group:Drink high calcium fresh milk
Control group:Drink regular fresh milk
Sponsors
Beijing Ditan Hospital, Capital Medical University
Eligibility
Sex/Gender
Female
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Women aged 40-75 years who have been postmenopausal for at least 1 year; 2. T score: t value is less than -1; 3. No symptoms of anorexia, intolerance or allergy to high calcium milk or other dairy products; 4. Stable living in Beijing and no plan to move out of Beijing in the past two years, stable eating habits, and able to cooperate with the completion of the research.
Exclusion criteria
Exclusion criteria: 1. Those who suffer from mental illness and cannot answer questions correctly or are unwilling to conduct questionnaires; those who cannot take care of themselves, cannot recall clearly and answer questions clearly, or have obvious movement disorders; 2. Suffering from any type of bone degenerative chronic disease (such as diabetes, kidney stones, remission of heart disease, cancer, hyperthyroidism and hypothyroidism, hyperparathyroidism, impaired kidney and liver function), history of traumatic fractures, Osteomalacia, renal osteodystrophy and other metabolic bone diseases or bone tumors; moderate or severe renal impairment (serum creatinine>2mg/dL or 177mmol/L), or abnormal liver function (ALT>2 times normal value) upper limit); moderate to severe chronic obstructive pulmonary disease; severe hypertension, cerebrovascular accident; 3. History of digestive system surgery, such as gastrectomy, fundoplication, colostomy, etc., or persistent vomiting or suspected digestive tract obstruction; 4. History of drug treatment, in the past 48 weeks, received hormone-related therapy to prevent postmenopausal diseases, or ingested anti-osteoporosis drugs and drugs that have an effect on bone metabolism, such as phenytoin, carbamazepine, etc.; or In the past 3 months, receiving drug treatment for the following diseases: cholecystitis, peptic ulcer, urinary tract infection, acute pyelonephritis, cystitis, hyperthyroidism and other abnormal thyroid function; 5. Patients with acute or chronic inflammatory diseases, or who are receiving antibiotics, probiotics, probiotics, or any other drugs that may affect the gut microbiota in the first 3 months of inclusion; 6. Suffering from infectious diseases such as tuberculosis and AIDS, and suffering from serious organic diseases, such as cancer, coronary heart disease, myocardial infarction and stroke; 7. Consuming other dietary supplements known to affect bone metabolism during treatment, including other milk, other soy milk, vitamin D, vitamin K, multivitamins and calcium tablets, etc., if this happens, they will be withdrawn from the group.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| bone density;blood metabolites; | — |
Countries
China
Contacts
Public ContactLiu Jun
Beijing Ditan Hospital, Capital Medical University
Outcome results
None listed