IgA Nephropathy
Conditions
Sponsors
Shandong Provincial Hospital
Eligibility
Sex/Gender
Male
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18~65, regardless of gender; 2. Primary IgAN has been confirmed by renal puncture biopsy; 3. 24h urine protein >= 1g/24h after 3 months of treatment with glucocorticoids combined with or without immunosuppressive agents and with or without ACEI/ARB; 4. eGFR>30mL/min /1.73m^2 5. Volunteers to participate in this study after signing the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Secondary IgA nephropathy, such as IgA vasculitis, viruses (HIV, hepatitis)infections, inflammatory bowel disease, autoimmune diseases, cirrhosis and other infectious factors; 2. Patients with severe chronic pathological changes: glomerulosclerosis or interstitial fibrosis>50%; 3. In the past 6 months, biological agents have been used for treatment, such as CD20 monoclonal antibody, belizumab, etc; 4. Patients newly receiving immunosuppressive therapy within 4 weeks before the start of the study; 5. Persons allergic to the study drugs; 6. Women during pregnancy or breastfeeding or preparing for pregnangy; 7. Patients with malignant tumors; 8. Patients who received surgical treatment within 4 weeks before the start of the study; 9. Subjects participating in other clinical trials; 10.In addition to the above, other circumstances that the researchers consider unsuitable to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of deterioration of renal function; | — |
Secondary
| Measure | Time frame |
|---|---|
| 24h urine protein;eGFR;Urine protein creatinine ratio(UPCR);serum creatinine;serum IgA;serum IgG;serum IgM; | — |
Countries
China
Contacts
Public ContactSun Jing
Shandong Provincial Hospital
Outcome results
None listed