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A Triple Blind Randomised Controlled Clinical Trial to Determine the Effectiveness of Government Recommended Mouthwashes in the Mitigation of Respiratory Pathogens (including COVID-19).

A Triple Blind Randomised Controlled Clinical Trial to Determine the Effectiveness of Government Recommended Mouthwashes in the Mitigation of Respiratory Pathogens (including COVID-19). - Pre-Procedural Mouth Rinsing in the Control of Respiratory Pathogens

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200064784
Enrollment
Unknown
Registered
2022-10-17
Start date
2022-10-17
Completion date
Unknown
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory Pathogens

Interventions

A:Povidone-iodine 1% w/v
B:Hydrogen peroxide 1.5%w/v
C:Chlorhexidine 0.2% w/v

Sponsors

Colman McGrath
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Be aged 18 or older 2. Be able to provide informed consent 3. Not taking any anti-viral, anti-bacterial or anti-fungal agents – topically or systemically (or in the past month) 4. No known allergy to mouth rinses.

Exclusion criteria

Exclusion criteria: 1. Pregnant or lactating 2. Currently taking any anti-viral, anti-bacterial or antifungal agents – topically or systemically (or in the past month) 3. Contraindications to use of mouth rinses such as active known allergies, thyroid disease, undergoing radioactive iodine therapy (may interact with PVP-I)

Design outcomes

Primary

MeasureTime frame
the prevalence of respiratory pathogens in saliva pre-mouth rinsing;the prevalence of respiratory pathogens in saliva posr-mouth rinsing;

Secondary

MeasureTime frame
the prevalence (and amount) of respiratory pathogens in the environmental from air samples pre-mouth rinsing;the prevalence (and amount) of respiratory pathogens in the environmental from air samples post-mouth rinsing;the prevalence (and amount) of respiratory pathogens from environmental swabbed of worksurface in the dental setting pre-mouth rinsing;the prevalence (and amount) of respiratory pathogens from environmental swabbed of worksurface in the dental setting post-mouth rinsing;Patient’s acceptance of pre-procedural mouth rinsing;

Countries

China

Contacts

Public ContactProf. Colman McGrath

University of Hong Kong

denhuang3@163.com28590513

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026