Postoperative pain
Conditions
Interventions
trial group:PCIA prescription : hydromorphone 0.1mg/Kg/48h combined with esketamine 1 mg/Kg/48h
control group:PCIA prescription:hydromorphone 0.2mg/Kg/48h
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age greater than 3 years but less than 12 years old; 2. ASA classification level 1-2; 3. Patients who plan to undergo elective abdominal surgery under general anesthesia; 4. Parents or guardians agree to use postoperative patient-controlled intravenous analgesia.
Exclusion criteria
Exclusion criteria: 1. Cognitive impairment of parents/caregivers or children resulting in inability to self report pain or answer research questions; 2. Has a history of allergic reactions to opioid drugs, ketamine, Esketamine, or their components in the past; 3. Severe obesity; 4. Severe sleep apnea syndrome; 5. A history of arrhythmia, bronchial asthma, acute upper respiratory tract infection, or the presence or possibility of difficult airways; 6. Abnormal recovery from previous surgical anesthesia; 7. Have a history of chronic pain and long-term use of analgesics; 8. Use analgesics, sedatives, or antipruritic drugs or quinolone antibiotics 24 hours before surgery; 9. Severe liver and kidney dysfunction; 10. ASA level 3 and above.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time weighted mean pain score at 24 h postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| FLACC scoring at 48 h after surgery;Opioid consumption in the first 48 h after surgery;Incidence of nausea and vomiting, hypoventilation, and pruritus within the first 48 h after surgery;Incidence of delirium in the first 3 postoperative days; | — |
Countries
China
Contacts
Public ContactYang Li
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed