Recovery of gastrointestinal function after colorectal cancer surgery
Conditions
Interventions
The experimental group:esketamine
Sponsors
Affiliated Hospital of Guangdong Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Preoperative clinical diagnosis of colorectal cancer patients; 2. 18 years old<=age<=75 years; 3. Planned laparoscopic radical resection of colorectal cancer under general anesthesia with tracheal intubation; 4. The preoperative ASA anesthesia score is I to III; 5. Hematology, liver and kidney functions are normal, and cardiopulmonary function tests indicate tolerability for surgery; 6. No preoperative radiotherapy or chemotherapy was received; 7. Able to understand and comply with the study, and sign an informed consent form to participate in this study.
Exclusion criteria
Exclusion criteria: 1. Preoperative intestinal diseases (such as ulcerative colitis, Krohn's disease and irritable bowel syndrome); 2. Patients at serious risk of elevated intracranial pressure; 3. Patients with poor control or untreated hypertension (resting blood pressure = 180/100mg); 4. Untreated or insufficiently treated patients with hyperthyroidism; 5. Patients with liver and kidney dysfunction; 6. Patients with allergies to anesthetic drugs (Esketamine); 7. Participate in other clinical studies within 3 months before surgery; 8. Failure to sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time of first postoperative anal exhaust; | — |
Secondary
| Measure | Time frame |
|---|---|
| Plasma C-reactive protein;Incidence of adverse reactions (nausea, vomiting, dizziness);Postoperative analgesia; | — |
Countries
China
Contacts
Public ContactCao Dianqing
Affiliated Hospital of Guangdong Medical University
Outcome results
None listed