Acute respiratory failure
Conditions
Interventions
Intervention group:Continuous dynamic invasive intrathoracic pressure monitoring
Control group:Traditional mechanical ventilation strategy
Sponsors
Shanghai fourth people's Hospital affiliated to Tongji University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Age>=18 years old, regardless of gender; 2. Meets the diagnostic criteria for ARF (ARDS), and the diagnosis of ARF does not exceed 48 hours after enrollment: 1) Within one week after the known cause, or after new or existing respiratory symptoms worsen; 2) Reduced transparency of both lungs, which cannot be fully explained by pleural effusion, atelectasis, or nodules; 3) Respiratory failure that cannot be explained by heart failure or excessive fluid load, if there are no risk factors, requires objective evaluation (such as cardiac ultrasound examination) to exclude pulmonary edema caused by increased hydrostatic pressure; 4) When PEEP/CPP>=5 cmH2O, PaO2/FiO2<=300mm Hg. 3. Conduct invasive mechanical ventilation and have bedside respiratory and circulatory monitoring facilities; 4. Informed consent.
Exclusion criteria
Exclusion criteria: 1. Recent major chest surgeries; 2. Existence of bronchopleural fistula; 3. Existence of solid organ transplantation; 4. Pregnancy; 5. There is severe coagulation dysfunction and severe decrease in platelets.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PaO2/FiO2 Ratio on 72h; | — |
Secondary
| Measure | Time frame |
|---|---|
| 28-day all-cause mortality;Mechanical ventilation support time;Other organ function support time;Incidence of nosocomial infection;Time of staying in ICU;Complications of mechanical ventilation (pressure sores, pneumothorax, etc.); | — |
Countries
China
Contacts
Public ContactJian Song
Shanghai fourth people's Hospital affiliated to Tongji University
Outcome results
None listed