early postoperative cognitive function and analgesia
Conditions
Interventions
Experimental group:Anesthesia induction is pre-given at a sub-anesthetic dose of esketamine
Sponsors
Quanzhou First Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 79 Years
Inclusion criteria
Inclusion criteria: 1. The patient is classified as I, II, and III according to the American Society of Anesthesiologists (ASA) anesthesia classification; 2. Patients aged 60-79 years old; 3. Not allergic to the drugs used in this study; 4. Those who plan to undergo laparoscopic gastrointestinal surgery.
Exclusion criteria
Exclusion criteria: 1. Those who have contraindications to general anesthesia or have had a history of anesthesia accidents in the past; 2. Severe abnormalities in cardiac function: acute heart failure, unstable angina, myocardial infarction within 6 months prior to screening, resting electrocardiogram heart rate=2.5 × ULNTBIL>=1.5 × ULN 6. Renal dysfunction: Urea nitrogen>=1.5 × ULN, blood creatinine greater than the upper limit of normal value; 7. History of alcoholism and drug abuse within one year, i.e. drinking more than 2 units of alcohol per day (1 unit=360 mL beer or 150 mL wine or 45 mL Baijiu with 40% alcohol); 8. Take opioid analgesics every day or intermittently for the past three months within a month; 9. Those who are allergic or contraindicated to propofol, opioid analgesics, and their drug components; 10. Have participated in any clinical trial as a subject within the past year; 11. The subject explicitly refused to participate in this study; 12. The researchers believe that patients should not participate in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure;Heart rate;Blood sugar; | — |
Countries
China
Contacts
Public ContactXie Wenqin
Quanzhou First Hospital
Outcome results
None listed