lumbar disc herniation
Conditions
Interventions
Group T:collagenase +PRP
Group C:collagenase
Sponsors
Shanghai Pudong Hospital; Fudan University Pudong Medical Center
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. meeting the diagnostic criteria of LDH; 2. symptoms of low back pain with unilateral limb radicular pain,VAS>=40mm,and had failed to conservative treatment for 6 weeks; 3. preoperative MRI showing patients with single-level disc herniation (L4-L5 or L5-S1),or only single segment needing surgery, which was consistent with clinical symptoms and signs; 4. patients aged 18-70 years old, with BMI 18.5-35kg/m2.
Exclusion criteria
Exclusion criteria: 1. size of disc herniation>10mm,with calcification, dissociation or prolapse; 2. spinal surgery history, intraspinal occupation, severe posterior longitudinal ligament calcification, grade II and above lumbar spondylolisthesis, and lumbar spinal stenosis; 3. severe neurological damagelike spinal cord degeneration, dyskinesia or cauda equina syndrome,etc; 4. allergy to collagenase or other therapeutic drugs; 5. PLT < 150×109/L, bleeding and coagulation dysfunction, or being treated with anticoagulation; 6. puncture contraindications like serious systemic diseases, mental disorders or infection,etc; 7. unable to cooperate to complete the operation, follow-up and functional training.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oswestry disability index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual analogue scale;Medical outcomes study 36-item short form health survey;Japanese orthopaedic association (JOA) scores;recurrence Rate;imaging data; | — |
Countries
China
Contacts
Public ContactZhilin Ni
Shanghai Pudong Hospital
Outcome results
None listed