Chronic venous insufficiency
Conditions
Interventions
The tolvaptan group:Take tolvaptan and adjust the dose
The placebo group:Take placebo
Sponsors
Guangzhou First People's Hospital
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. The subjects volunteered to cooperate with the study and signed an informed consent; 2. Patients admitted with chronic venous insufficiency; 3. Age: >=65 years old; 4. Patients with complete clinical data.
Exclusion criteria
Exclusion criteria: 1. Treatment with diuretic, dihydroergotamine, or intravenous active drugs in the past 6 weeks; 2. Patients with severe liver and renal impairment; 3. Patients with uncontrolled hypertension (systolic blood pressure >=180mmHg or diastolic blood pressure >=110mmHg); 4. Patients complicated with malignant tumors; 5. Cardiogenic or renal oedema; 6. Severe varicose veins require surgical treatment; 7. Having undergone varicose vein surgery; 8. Malicious ulcer; 9. Congenital vascular malformation; 10. Those who have participated in clinical trials of any other drugs or medical devices within 2 months before the screening.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Leg circumference / ankle circumference;Chronic venous insufficiency questionnaire; | — |
Secondary
| Measure | Time frame |
|---|---|
| Fasting weight;Urinary volume at 24 hours;6-min walking distance;Blood sodium;Urinary AQUA2 levels;Liver and kidney function;Lower limb vascular color ultrasound; | — |
Countries
China
Contacts
Public ContactYang Chongzhe
Guangzhou First People's Hospital
Outcome results
None listed