Uterine leiomyoma
Conditions
Interventions
Operation group:Transabdominal operation
HIFU group:HIFU ablation
Sponsors
Affiliated Hospital of Zunyi Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 52 Years
Inclusion criteria
Inclusion criteria: 1. Patients with premenopausal uterine fibroids diagnosed clinically and radiographically; 2. Patients with uterine fibroids who plan to undergo a HIFU ablation or surgical resection; 3. 2.5cm<maximum diameter of uterine fibroids<10cm; 4. Patients who plan to undergo hysterectomy due to other gynecological benign diseases complicated with uterine fibroids; 5. Patients are generally in good condition, and there is no language communication barriers.
Exclusion criteria
Exclusion criteria: 1. The number of uterine leiomyomas in one ablation is>=2; 2. Patients who have previously received HIFU therapy or are undergoing other treatments; 3. Patients contraindicated to MRI examination or contrast media; 4. Patients with adenomyosis, acute inflammation of the pelvic or reproductive tract, or severe systemic diseases; 5. Patients with confirmed or suspected uterine malignancy, fibroid degeneration or potential malignant transformation; 6. The volume data of target fibroids cannot be completely collected by transvaginal three-dimensional ultrasound or there is no independent acquisition window; 7. Uterine fibroids comminuted by laparoscopy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean vessel density;Vascular index;Flow index;Vascularization-flow index;Vascular network of uterine leiomyoma;Signal intensity of T1WI;Non-perfusion volume ratio; | — |
Secondary
| Measure | Time frame |
|---|---|
| Signal intensity of T2WI;Uterine leiomyoma volume;Therapeutic energy;Treatment time;Sonication time;Sonication power;Therapeutic intensity;Energy Efficiency Factor, EEF;Residual volume; | — |
Countries
China
Contacts
Public ContactHao Qiong
Affiliated Hospital of Zunyi Medical University
Outcome results
None listed