Spinal diseases
Conditions
Interventions
Group A:Patients were intravenously infused with tranexamic acid before skin incision, and the same amount of normal saline or other placebo was used at the same time point as group B after operation.
Group B:Patients received intravenous infusion of tranexamic acid before skin incision and tranexamic acid at different time points after operation.
Sponsors
The First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. The diagnosis of our hospital is: (1) Lumbar degenerative disease; (2) Cervical degenerative disease; (3) Thoracic degenerative diseases; (4) Adolescent idiopathic scoliosis; (5) Spinal kyphosis; (6) Spinal tumors; (7) Spinal fractures; (8) Spine-related diseases such as spinal tuberculosis, and patients who need spinal-related surgery; 2. Those who voluntarily joined the study and signed informed consent; 3. Preoperative hemoglobin (Hb) and coagulation function were normal; 4. No abnormal lower extremity venous ultrasound.
Exclusion criteria
Exclusion criteria: 1. Preoperative anemia (Hb: female III; 8. Patients with history of any psychiatric illness; 9. Patients who have undergone lumbar surgery in the past; 10. Patients combined with lumbar tumour, tuberculosis, infection or lumbar vertebral fracture caused by trauma.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Basic demographic parameters ( age, gender, height, weight, etc. );Blood loss related parameters (total blood loss,postoperative blood loss, dominant blood loss, hidden blood loss, intraoperative blood loss, drainage fluid blood content, etc. );Bood routine (Hct, Hb, RBC, PLT);Coagulation and fibrinolysis indexes (PT, INR, APTT, TT, FIB, FDP, D-D);Coagulation factors (II, V, VII, VIII, IX, X, XI, XII);Liver and kidney function (ALb, ALT, AST, BUN, Cr);Inflammatory response related indicators;Thrombelastogram (TEG);Length of stay ( total length of stay, preoperative length of stay, postoperative length of stay, etc. );Drainage tube removal time, postoperative bed rest time to ambulation time, etc.;Postoperative complication(exudation, hematoma, infection, etc.);The incidence of thrombosis (deep vein thrombosis, muscular calf vein thrombosis, pulmonary embolism, myocardial infarction, etc.);Medical expenses;Duration of operation (min), length of incision (cm);Postoperative wound drainage volume, HCT of postoperative wound drainage fluid;Pain-related parameter indicators;Anesthesia related parameters ( ASA classification, cardiopulmonary function classification, Mallampati classification, etc. );Clinical diagnosis, past history, osteoporosis, etc.;Chalybeate, EPO, anti-inflammatory and analgesic drugs and other drugs use and follow-up.; | — |
Countries
China
Contacts
Public ContactZhenming Hu
The First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed