Perioperative neurocognitive disorder
Conditions
Interventions
Remimazolam tosilate group:Total intravenous anesthesia with remimazolam tosilate
Propofol group:Total intravenous anesthesia with propofol
Sponsors
National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Male and female patients aged between 65 and 90 years old; 2. ASA physical status I-III; 3. Scheduled to undergo uniportal video-assisted thoracic surgery (VATS) lobectomy with expected duration of 2 hours to 4 hours, and an anticipated hospital stay of at least 5 days; 4. Body-mass index (BMI) between 18 and 27.9 kg/m2.
Exclusion criteria
Exclusion criteria: 1. Diagnosis of severe respiratory, cardiovascular, renal or hepatic dysfunction before surgery; 2. Hemoglobin < 90 g/L; 3. Had a history of stroke or any other central nervous system disease within 6 months; 4. Had a history of schizophrenia, epilepsy, Parkinsonism, myasthenia gravis or other mental illness; 5. Alcoholism or history of psychotropic substance dependence; 6. Inability to communicate because of severe visual, auditory or verbal problems; 7. Allergies or contraindications to propofol or benzodiazepines; 8. The Mini-Mental State Examination (MMSE) score <24 or delirium existed evaluated by confusion assessment method (CAM) 3 min diagnostic interview (3D-CAM) at baseline; 9. Receive radiotherapy, chemotherapy or immunotherapy; 10. Participated in other drug trials within 1 preoperative month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative delirium within 5 days; | — |
Secondary
| Measure | Time frame |
|---|---|
| Onset time and duration of delirium;Cognitive function within 30 days after surgery;Cognitive function within 1 year after surgery;Postoperative analgesia within 5 days;Postoperative recovery;Related inflammatory biomarkers;Postoperative chronic pain within 3 months; | — |
Countries
China
Contacts
Public ContactYan Tao
National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Outcome results
None listed