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Intravenous injection of human immunoglobulin was given to prevent cholangitis after Kasai in children with biliary atresia

A randomized controlled clinical study on prevention of cholangitis by intravenous injection of human immunoglobulin after Kasai in children with biliary atresia

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200064635
Enrollment
Unknown
Registered
2022-10-13
Start date
2022-10-24
Completion date
Unknown
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Biliary atresia

Interventions

Treatment group:Iv infusion of human immunoglobulin, 400mg/kg/ time, for 5 days
Control group:Conventional therapy

Sponsors

The First Affiliated Hospital of Guangxi Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
No minimum to 0.3 Years

Inclusion criteria

Inclusion criteria: 1. The diagnostic criteria for biliary atresia were met. Laparotomy or laparoscopy implemented biliary imaging examination is the only way of diagnosis, imaging can clearly display of bile duct of liver inside and outside situation, first of all, the gallbladder puncture for white bile, gallbladder catheter injection concentration 30% o is peck or shadow meglumine, distal bile duct unobstructed and proximal development must be oppressed common bile duct contrast again, if still no intrahepatic bile duct contrast enhancement can diagnosis of biliary atresia. Hilar liver cyst can also be directly punctured cyst angiography. Biliary atresia should be diagnosed when gallbladder atrophy is impossible for catheterization; 2. Age 0-180 day, male or female; 3. The subjects' families were able to sign informed consent forms, comply with the restrictions and requirements of the study protocol, and the investigator believed that the subjects could complete the study.

Exclusion criteria

Exclusion criteria: 1. The subjects were judged to be non-biliary atresia during surgery; 2. Subjects had received intravenous human immunoglobulin before surgery.

Design outcomes

Primary

MeasureTime frame
Blood routine;CRP;Liver function;

Countries

China

Contacts

Public ContactZhang Hongliang

The First Affiliated Hospital of Guangxi Medical University

277749097@qq.com+86 13737143253

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026