A Randomized Clinical Trial Comparing the Effect of Phenylephrine and norepinephrine in Elderly Undergoing Major Abdominal Surgery

A Randomized Clinical Trial Comparing the Effect of Phenylephrine and norepinephrine combined with Fluid Guided Therapy respectively in Elderly Undergoing Major Abdominal Surgery

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200064604

Enrollment

Unknown

Registered

2022-10-12

Start date

2022-10-12

Completion date

Unknown

Last updated

2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Radical resection of gastric and colorectal cancers, pancreaticoduodenectomy

Interventions

Phenylephrine (PE):When hypotension occurred,Patients received PE infusion at a starting rate of 5 ml/h of 100µg/ml solution (prepared by diluting 10 mg of PE in 100 ml saline)

Norepinephrine (NE):When hypotension occurred,Patients received NE infusion at a starting rate of 5 ml/h of 8 ug/ml solution (prepared by diluting 2 mg NE in 250 ml saline)

Eligibility

Sex/Gender

All

Age

65 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. Male or female patients, aged 65-85 years old; 2. Radical resection of colorectal or gastric cancers pancreaticoduodenectomy; 3. Surgical time >=2 hours; 4. The American Society of Anesthesiologists(ASA) classification of II or III; 5. NYHA classification I-II.

Exclusion criteria

Exclusion criteria: 1. History of severe cerebrovascular disease; 2. Arrhythmia, left ventricular ejection fraction =B); 6. Renal insufficiency (serum creatinine > 50% of the upper limit of normal); 7. History of hematological diseases and severe endocrine diseases; 8. Enrollment in another drug trial within 30 days before informed consent; 9. History of neuropsychiatric system: craniocerebral trauma, possible convulsion, history of intracranial hypertension; Patients with schizophrenia, mania, psychosis, long-term use of psychotropic drugs, disturbance of consciousness, and history of cognitive dysfunction were unable to give informed consent.

Design outcomes

Primary

Measure	Time frame
First flatus time after surgery;All complications, all-cause mortality, and readmission rates within 28 days after surgery;	—

Secondary

Measure	Time frame
Hemodynamic index;Tissue perfusion and oxygenation;Fluid intake and output and The doses of all other medications used during surgery;	—

Countries

China

Contacts

Public ContactZhaoyang Xiao

Second Affiliated Hospital of Dalian Medical University

411084637@qq.com+86 17709873399

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026