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Multiomics study on the pathogenesis of postpartum depression

Effects of metabolic biomarkers and gut microbiota on postpartum depression after cesarean section

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2200064595
Enrollment
Unknown
Registered
2022-10-12
Start date
2021-08-01
Completion date
Unknown
Last updated
2023-07-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postpartum depression

Interventions

Group PPD:N/A
Group HC:N/A

Sponsors

West China University Hospital, Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1. Patients performed an elective cesarean section and agreed to participate in the trial in West China the second Hospital of Sichuan University; 2. Patients who were 20 to 40 years old, single child, gestational age >= 37 weeks, scheduled cesarean section under combined epidural anesthesia; 3. 12 Lead electrocardiogram (ECG) was normal, blood routine was normal, coagulation function was normal, and there was no contraindication of intraspinal anesthesia.

Exclusion criteria

Exclusion criteria: 1. Artificial insemination, unwanted pregnancy, thyroid dysfunction and anemia, HIV or other infectious diseases, pregnant women diagnosed with fetal abnormalities; 2. History of alcohol or drug abuse, other diseases that may be related to neuropsychological impairment, such as major physical or neurological diseases, head injury, drug abuse or dependence, and history of mental retardation; 3. Pregnant women who were diagnosed with obsessive-compulsive disorder, eating disorder, bipolar disorder or schizophrenia within 12 months before the screening and were treated with antidepressants; 4. Patients with a major disease that may affect research participation or data interpretation; 5. Users of antibiotics and intestinal probiotics, patients with intestinal diseases, and those who use local anti-constipation drugs to assist defecation.

Design outcomes

Primary

MeasureTime frame
Hamilton Depression Scale;

Countries

China

Contacts

Public ContactTao Li

West China University Hospital, Sichuan University

scutaoli1981@scu.edu.cn+86 189 8060 6762

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026