Radiation-induced oral mucositis
Conditions
Interventions
Group 1 :Concurrent chemoradiotherapy (CCRT) combined with atomized inhalation of salpeilin
Group 2:CCRT combined with dexamethasone aerosol inhalation
Sponsors
Affiliated Hospital of Guangdong Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients with locally advanced nasopharyngeal carcinoma (stage II-IV, AJCC 8th edition) pathologically diagnosed by a tertiary hospital; 2. Have not received radiotherapy, chemotherapy, surgery, immunization, targeted therapy, etc. in the past; 3. KPS score >= 70 points; 4. The oral mucosa is intact and normal before treatment; 5. Age: 18-75 years old; 6. Voluntary participation and written informed consent; 7. Blood routine: white blood cells >= 4.0 x 10^9/L; hemoglobin >= 100 g/L; neutrophil count >= 1.5 x 10^9/L; platelet count >= 100 x 10^9/L; 8. Biochemical examination: total bilirubin = 60 ml/min; 9. Cardiopulmonary function is basically normal.
Exclusion criteria
Exclusion criteria: 1. Patients with severe heart, liver, kidney damage or bone marrow dysfunction; 2. Suffering from other malignant tumors in the past or now, or distant metastasis during treatment; 3. Surgery, radiotherapy and chemotherapy, targeted and immunotherapy have been performed; 4. I or my immediate family members have a history of allergic diseases such as bronchial asthma, rash, and urticaria; 5. According to the investigator's judgment, there are concomitant diseases that seriously endanger the patient's safety or affect the patient's completion of the study, such as heart disease, kidney disease, and patients with acute infectious diseases; 6. Female patients who are breast-feeding, pregnant or planning to become pregnant during the study period; 7. Those who are known to be allergic to the therapeutic drugs and penicillin used in the experiment; 8. Those with mental or nervous system disorders or poor compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of radiation-induced oral mucositis;Oral cavity mucous membrane; | — |
Secondary
| Measure | Time frame |
|---|---|
| RTOM occurrence time and duration; | — |
Countries
China
Contacts
Public ContactLuo Haiqing
Affiliated Hospital of Guangdong Medical University
Outcome results
None listed