esophageal superficial cancer and precancerous lesion
Conditions
Interventions
Group 1 :TA-filling and oral prednisone
Group 2:endoscopic TA local injection and oral prednisone
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Superficial esophageal cancer and precancerous lesions diagnosed by white light endoscopy + electronic chromoendoscopy, biopsy pathology, and endoscopic ultrasound; 2. A single lesion is expected to reach 3/4 or more of the esophageal circumference after resection, or multiple lesions are at the same level and the expected horizontal range of the wounds after resection reaches 3/4 or more of the esophageal circumference; 3. The length of the wound reaches 3 cm or more; 4. Preoperative CT excluded lymph nodes and distant metastasis.
Exclusion criteria
Exclusion criteria: 1. Previously received endoscopic or other recurrent lesions on the basis of treatment; 2. There are contraindications to anesthesia, ESD treatment or application of glucocorticoids; 3. Combined with swallowing dysfunction, severe head, neck and chest infection and other basic diseases; 4. The muscularis propria of the esophagus is obviously damaged or perforated during ESD; 5. Patients undergoing surgery for endoscopic non-curative resection prior to complete epithelialization of the wound.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence of stenosis; | — |
Secondary
| Measure | Time frame |
|---|---|
| total number of additional TA-filling procedures;time to initial stenosis;time to complete re-epithelialization without stenosis;dysphagia score;total number of endoscopic balloon/bougie dilatation procedures; | — |
Countries
China
Contacts
Public ContactLong Rong
Peking University First Hospital
Outcome results
None listed