Prediction and mechanism of Post-Transplant Diabetes Mellitus based on serum metabolomics

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2200064535

Enrollment

Unknown

Registered

2022-10-11

Start date

2022-11-01

Completion date

Unknown

Last updated

2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

diabetes

Interventions

Group 1 :

Group 2:

Eligibility

Sex/Gender

All

Age

20 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Orthotopic liver transplantation for the first time; 2. Adopt a tacrolimus-based immunosuppressive regimen after surgery; 3. Gender is not limited, age between 20-70 years old; 4. Regular follow-up visits can be carried out in the hospital, and blood drug concentration testing can be carried out; 5. The follow-up time is more than 45 days.

Exclusion criteria

Exclusion criteria: 1. Multiple organ transplantation; 2. Donor-recipient ABO blood type incompatibility; 3. Preoperative diabetic patients; 4. Severe infection that is difficult to control; 5. Died or lost contact during the follow-up period; 6. Two or more organ transplants; 7. Switch the immunosuppressive regimen midway.

Design outcomes

Primary

Measure	Time frame
blood glucose;	—

Secondary

Measure	Time frame
glycosylated hemoglobin;Tacrolimus concentration;cholesterol;triglyceride;Low density lipoprotein;High density lipoprotein;Alanine aminotransferase;Serum creatinine;Urea nitrogen;	—

Countries

China

Contacts

Public ContactWang Min

Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School

wangmin19881013@126.com+86 15051872754

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026