patients with recurrent implantation failure and endometriosis
Conditions
Interventions
Experimental group:intrauterine perfusion of platelet-rich plasma
Conrol group:intrauterine perfusion of HCG
Sponsors
The Second People’s Hospital of Shenzhen, The First Affiliated Hospital of Shenzhen University
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Age 20-40 years old; 2. Meet the diagnostic criteria for repeated implantation failure: embryo implantation failure for 3 or more consecutive embryo transfer cycles (including fresh and frozen transfer cycles), accumulatively transfer at least 4 high-quality embryos and fail to achieve clinical pregnancy; 3. Meet the diagnostic criteria of endometriosis; 4. Patients have reproductive requirements, voluntarily participate in this study and sign the informed consent (see informed consent).
Exclusion criteria
Exclusion criteria: 1. Unilateral or bilateral hydrosalpinx, uterine cavity effusion; 2. Those with organic lesions (endometrial polyps) and intrauterine adhesions in the uterus and uterine cavity, and endometrial tuberculosis; 3. The woman should not be pregnant or the original disease will be exacerbated after pregnancy, and serious cases will threaten life safety, such as severe heart disease, nephritis, hepatitis, etc.; 4. The woman's genitals are severely underdeveloped or deformed; she suffers from acute infection or sexually transmitted disease. Suffering from severe genetic, physical or mental illness; 5. Either party has serious bad habits, cognitive impairment, exposure to teratogenic doses of radiation, poisons, drugs, and due to the period of action or abnormal chromosomal karyotype.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the implantation rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| the clinical pregnancy rate;the biochemical pregnancy rate;the early miscarriage rate;the ongoing pregnancy rate; | — |
Countries
China
Contacts
Public ContactLi Ying
The Second People’s Hospital of Shenzhen, The First Affiliated Hospital of Shenzhen University
Outcome results
None listed