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The effect of Chiglitazar on T cell subsets and endothelial progenitor cells in elderly patients with type 2 diabetes mellitus and its mechanism in diabetic vascular disease

The effect of Chiglitazar on T cell subsets and endothelial progenitor cells in elderly patients with type 2 diabetes mellitus and its mechanism in diabetic vascular disease

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200064497
Enrollment
Unknown
Registered
2022-10-10
Start date
2022-11-01
Completion date
Unknown
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes mellitus and its vascular complications

Interventions

Experimental group:Chiglitazar

Sponsors

The First Affiliated Hospital of Chengdu Medical College
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Patients who met the diagnostic criteria for type 2 diabetes, aged 18-80 years; Patients aged >=60 years, glycated hemoglobin >7%, and diabetic vascular complications were included in the experimental group. The newly diagnosed patients with type 2 diabetes without vascular complications were included in the control group; 2. HBA1C <9.0%; 3. Informed consent was signed by the patient or his/her guardian before screening.

Exclusion criteria

Exclusion criteria: 1. Those who are participating in the intervention study and taking rosiglitazone or biglitazone; 2. Pregnant and lactating patients, gestational diabetes mellitus or diabetes mellitus combined with pregnancy; 3. Severe kidney disease, eGFR< 45ml/min/1.73m^2; 4. Status of tumor chemotherapy and radiotherapy; 5. Allergy to siglitat sodium; 6. Patients with other mental diseases who are unable or unwilling to cooperate; Or other conditions that the researcher deems inappropriate to study.

Design outcomes

Primary

MeasureTime frame
T cell subsets;Endothelial progenitor cells;Vascular complications;

Countries

China

Contacts

Public ContactMei Xi

The First Affiliated Hospital of Chengdu Medical College

messi0802@163.com+86 15828386662

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026