None listed
Conditions
Interventions
Control group:equal volumes of saline
Experimental group:esketamine
Sponsors
The Third Affiliated Hospital of Southern Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-70 years; 2. Posterior lumbar fusion should be performed at an appropriate time; 3. BMI 18-35 (kg/m^2); 4. PCA after surgery; 5. Sign informed consent voluntarily.
Exclusion criteria
Exclusion criteria: 1. Increased intracranial pressure and intraocular pressure; 2. Poor preoperative blood pressure control (basic blood pressure > 180/100mmHg); 3. Patients with mental illness and cognitive dysfunction; 4. Inability to understand pain scale or recovery quality scale; 5. Severe cardiac insufficiency (myocardial infarction, heart failure, malignant arrhythmia); 6. Liver dysfunction (total bilirubin > 2mg/dl); 7. Patients with renal insufficiency (glomerular filtration rate 2 weeks; 10. Allergy to the drug being tested; 11. Patients with myasthenia gravis; 12. Patients with history of malignant hyperthermia; 13. Patients with epilepsy; 14. Patients with a history of cerebrovascular accidents; 15. Patients with active gastrointestinal bleeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality of recovery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure and heart rate;Postoperative sedation-agitation score;Postoperative pain score;Extubation time of endotracheal tube;Time to get out of bed after surgery ;Length of hospital;Postoperative exhaust time;PACU time;Intraoperative dosage of propofol, ephedrine and atropine;Postoperative cumulative opioids consumption;Recovery time;Adverse outcome;Times of remedial analgesia; | — |
Countries
China
Contacts
Public ContactZhou Jun
Outcome results
None listed