Lynch syndrome associated gynecological malignancies
Conditions
Interventions
Group CC:None
Group EC:None
Group OC:None
Sponsors
Peking Union Medical College Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Aged at least 18 years and willing to participate in this study; 2. EC/OC/CC was confirmed by cytology or histopathology; 3. Be able and willing to provide enough tumor/normal samples for testing; 4. If the classification is dMMR or MSI-H/L, you can and are willing to provide normal somatic cell samples for embryonic line gene detection; 5. The functions of heart, liver, kidney, bone marrow and other important organs are normal or basically normal; 6. ECOG PS score is 0-1, and the expected life span is more than 3 months.
Exclusion criteria
Exclusion criteria: 1. The patient has any active autoimmune disease or has a history of autoimmune disease; 2. Any other disease or condition with clinical significance that the investigator thinks may affect the compliance of the scheme, or affect the patient to sign the informed consent, or is not suitable to participate in this clinical trial; 3. The pathological tissue sample cannot meet the detection requirements; 4. Loss of follow-up or death within 1 month after operation; 5. Incomplete key clinical information.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mismatch repair defects;Microsatellite instability; | — |
Countries
China
Contacts
Public ContactWu Ming, Yin Rutie
Peking Union Medical College Hospital
Outcome results
None listed