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Predicting treatment response and relapse for rheumatoid arthritis patients via GLOESS-based ultrasound scoring and clinical indexes: a prospective observational study

Predicting treatment response and relapse for rheumatoid arthritis patients via GLOESS-based ultrasound scoring and clinical indexes: a prospective observational study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2200064477
Enrollment
Unknown
Registered
2022-10-09
Start date
2022-09-26
Completion date
Unknown
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rheumatoid Arthritis (RA)

Interventions

Case series:None

Sponsors

Shenzhen Hospital of Peking University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1. Part I selection criteria: (1) Diagnosed with rheumatoid arthritis on the basis of ACR2010; (2) Aged over 18 years; (3) Inflammatory lesions in at least one small joint (MCP, PIP, wrist); (4) Moderate and severe disease activity; (5) Prepare to receive new treatment options (conventional DMARDs, biological DMARDs, targeted DMARDs), prescribed by a senior and experienced rheumatologist; (6) Maintain a steady dose of the drug for at least 6 weeks before a new course of treatment; (7) Strictly follow the treatment plan and visit schedule; Discontinuation of medication and loss of follow-up will be excluded. 2. Part II inclusion criteria: (1) Diagnosed with rheumatoid arthritis on the basis of ACR2010; (2) Aged over 18 years; (3) CR achieved clinical remission after standard treatment; (4) At least one facet joint had previously developed arthritic lesions; (5) Prepare to stop or reduce the drug.

Exclusion criteria

Exclusion criteria: 1. Unwilling to participate in research or undergo imaging; 2. Unable to complete the study due to physical or mental limitations; 3. Serious adverse events occurred during the study; 4. Complications with other types of arthritis, including osteoarthritis, psoriatic arthritis and gouty arthritis.

Design outcomes

Primary

MeasureTime frame
Prognostic area under the curve (AUC);

Secondary

MeasureTime frame
Sensitivity;Specificity;Accuracy;

Countries

China

Contacts

Public ContactXie Haiqin

Shenzhen Hospital of Peking University

xiehaiqin@126.com+86 13922802885

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026