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Study on the mechanism of exosome miRNA mediated autophagy in temporal lobe epilepsy

Effect of Chaihu Longgu Muli decoction on serum exosomes in patients with epilepsy

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200064447
Enrollment
Unknown
Registered
2022-10-08
Start date
2022-10-01
Completion date
Unknown
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

temporal lobe epilepsy (TLE)

Interventions

Oxcarbazepine group:Take oxcarbazepine
Oxcarbazepine+CLMD group:Take oxcarbazepine+CLMD
Control group:None

Sponsors

Hu'nan Brain Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Consistent with the diagnosis of epileptic syndrome in the tenth edition of TCM Internal Medicine published by China Traditional Chinese Medicine Press; 2. TLE diagnostic criteria refer to the relevant criteria of the International Anti-Epileptic League in 2005; 3. No focal nervous system signs were found by neurological examination; 4. The patient was examined by electroencephalogram (EEG) and analyzed with BESA5.1.2 dipole localization software and found that the origin of epilepsy was clearly the temporal lobe; 5. Aged 18-60 years; 6. All patients and their families have signed informed consent forms.

Exclusion criteria

Exclusion criteria: 1. Abnormal liver and kidney function (ALT, AST, Cr, BUN more than 1.2 times the normal value); 2. Allergic to experimental drugs; 3. Complicated with heart, liver, kidney and other vital organ diseases, as well as serious diseases affecting their survival, such as malignant tumors; 4. Prepare for pregnancy, pregnancy or breastfeeding.

Design outcomes

Primary

MeasureTime frame
Exosomes;Exosome proteome;

Countries

China

Contacts

Public ContactYang Ping

Hu'nan Brain Hospital

cuteping12384@126.com+86 15111069360

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026