Early esophageal cancer and precancerous lesions
Conditions
Interventions
traditional ESD group:Auxiliary traction
dental floss clip traction endoscopic submucosal dissection (ESD) group:Auxiliary traction
Sponsors
Second People's Hospital of Shandong Province
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients aged >=18 years, no gender limit, who agree to undergo esophageal ESD; 2. Lesion length >=2cm; 3. Preoperative white light, iodine staining, narrow band imaging with magnify endoscopy (NBI+ME) and endoscopy were performed.EUS and chest CT showed that the lesion was confined to M1, M2, M3 or SM1 without vascular or lymphatic metastasis (SM1 layer refers to the upper 1/3 layer of submucosa); 4. Early esophageal cancer or precancerous lesions confirmed by preoperative endoscopic biopsy pathology:low grade intraepithelial neoplasia (LGIN) High grade intraepithelial neoplasia (HGIN) or moderate to severe atypical hyperplasia.
Exclusion criteria
Exclusion criteria: 1. Lymph node metastasis or distant metastasis exists; 2. The tumor has invaded the musculi propria; 3. Severe bleeding tendency (prothrombin time > 14s or platelet count < 90x10^9/L). For patients who need to take anticoagulants for a long time due to cardiovascular problems, the anticoagulants should be stopped for at least 3-7 days before surgery, even if the coagulation function is within the normal range, and then again for 3-7 days); 4. Negative mucosal uplift sign; 5. Patients with iodine allergy; 6. Patients with severe heart, liver and kidney insufficiency, severe neuropathy or mental disease; 7. Pregnant or lactating patients; 8. Refuse endoscopic therapy for those who are considered unsuitable for the physical examination of this project by the researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ESD operation time;Disease stripping time;Stripping speed per unit time;Number of postoperative complications and their specific situation; | — |
Countries
China
Contacts
Public ContactWei Zhi
Outcome results
None listed