Breast Cancer
Conditions
Interventions
group A:General anesthesia of Sevoflurane
group B:General anesthesia of Sevoflurane+paravertebral nerve block(PVB)
group C:General anesthesia of Sevoflurane+pectoral nerves block-?(PECS-?)
Sponsors
National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Eligibility
Sex/Gender
Female
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients who voluntarily participated in the study and signed written informed consent; 2. Female aged 18-70 years at the time of signing the informed consent; 3. Histological or cytological confirmation of breast adenocarcinoma; 4. Surgical treatment under elective general anesthesia is proposed; 5. American society of anesthesiologists (ASA) grades ?-?.
Exclusion criteria
Exclusion criteria: 1. Patients with inflammatory diseases; 2. Patients who received surgical treatment within the last 30 days; 3. Pregnant patients; 4. Patients with kidney disease; 5. Long-term use of sedatives or antidepressants and other psychotropic drugs; 6. Contraindicated regional nerve block; 7. Difficulties in language comprehension, mental illness, inability to visit hospitals for follow-up visits, etc.; 8. Taking other investigational drugs or participating in other clinical trials within the 3 months prior to study inclusion; 9. Preoperative radiotherapy or chemotherapy; 10. Other conditions not considered suitable for inclusion in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative chronic pain within 3 months; | — |
Secondary
| Measure | Time frame |
|---|---|
| explore the analgesic effects of different blocking techniques under different degrees of surgical trauma;compare the expression of ASC, pro-caspase-1, caspase-1 and IL-1ß & IL-18 in NLRP3 inflammasome signal pathway in peripheral blood monocytes before/or 1 day after operation;explore the effect of pain on tumor prognosis;establishment and validation of CPSP prediction model for breast cancer;postoperative serum expression of NLRP3 inflammasome in peripheral blood monocytes; | — |
Countries
China
Contacts
Public ContactYan Tao
National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Outcome results
None listed