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The mechanism of Nrf2/Keap1 signaling pathway regulating BDNF-induced nociceptive sensitization in osteoarthritis

The mechanism of Nrf2/Keap1 signaling pathway regulating BDNF-induced nociceptive sensitization in osteoarthritis

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2200064427
Enrollment
Unknown
Registered
2022-10-07
Start date
2022-10-01
Completion date
Unknown
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

osteoarthritis

Interventions

Osteoarthritis group:none
Control group:none

Sponsors

Suzhou Municipal Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
50 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Aged 50-75 years; 2. No gender limit; 3. Informed consent was signed by the patient or authorized family member.

Exclusion criteria

Exclusion criteria: 1. Participated in other clinical trials within 4 weeks before the study began; 2. Revision patients after joint replacement; 3. Patients with severe cardiovascular and cerebrovascular diseases who cannot tolerate surgery; 4. Brain disease, abnormal judgment ability; 5. The patient requested that the trial be terminated.

Design outcomes

Primary

MeasureTime frame
Expression of Nrf2;Expression of MAGL;—

Secondary

MeasureTime frame
Synovial inflammation;—

Countries

China

Contacts

Public ContactGu Chengyong

Suzhou Municipal Hospital

gcygcy1979@163.com+86 13862169052

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026