Vocal cord polyps
Conditions
Interventions
Experimental group:Different doses of sufentanil
Sponsors
Yichang Central People's Hospital of Hubei Province
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-65 years; 2. ASA I or II; 3. Estimated anesthesia operation time <=120min; 4. BMI 14~23.9kg/m^2.
Exclusion criteria
Exclusion criteria: 1. Patients with a history of opioid allergy; 2. Analgesics, sedatives, antiemetics and antipruritic drugs were used 24 hours before surgery; 3. Patients with body temperature higher than 38°C or with symptoms of acute upper respiratory tract infection within 24 hours before surgery; 4. Patients with a history of bronchial asthma; 5. Patients diagnosed with moderate to severe sleep apnea syndrome before surgery; 6. Patients with difficult airway or a history of abnormal anesthesia recovery in the preoperative assessment; 7. Renal function damage (BUN and or Cr> the upper limit of normal); 8. Liver function damage (ALT and or AST>1.5 times the upper limit of normal); 9. Patients with a history of severe head trauma and intracranial hypertension within 6 months; 10. Patients with mental or neurological diseases, or patients who cannot correctly express their wishes; 11. Patients with a history of taking long-term sedative and analgesic drugs or monoamine oxidase inhibitors; 12. Expected surgical blood loss greater than 100ml; 13. Those who have participated in clinical trials of other drugs within the past month; 14. Patients who cannot be scored by ASA or FLACC for various reasons; 15. Patients who are accompanied by other conditions, and the researchers think that they are not suitable for inclusion; 16. Abnormal breath-holding test; 17. Have not quit smoking within the last half month; 18. Hypertensive patients or those with arrhythmias.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The extent of sufentanil induced choking (SIC);Degree of choking induced by extubation (EIC);Score for throat pain;ED50 for EIC;ED50 for SIC;ED50 for throat pain;Hemodynamic parameters within five minutes after induction of intubation;Number of cases with related adverse events; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of analgesic use;Incidence of nausea and vomiting;Time for extubation; | — |
Countries
China
Contacts
Public ContactGong Yuan
Yichang Central People's Hospital
Outcome results
None listed