Adolescent growth hormone deficiency
Conditions
Interventions
Intervention group:PEGylated recombinant human growth hormone, administered once a week, in combination with triptorelin, once every 28 days
Control group:PEGylated recombinant human growth hormone, administered once a week
Sponsors
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Conditions for the diagnosis of growth hormone deficiency: (1) Height 4 mL. 3. The bone age of girls is less than or equal to 12 years old, and the bone age of boys is less than or equal to 14 years old. 4. No recombinant human growth hormone therapy within 3 months.
Exclusion criteria
Exclusion criteria: 1. IGF-1 level > 3SD; 2. Chromosomal abnormality or any significant concomitant disease that may interfere with growth or research; 3. Patients with contraindications to recombinant human growth hormone or GnRHa therapy; 4. Concomitant deficiency of at least one other pituitary hormone.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Predict adult height; | — |
Secondary
| Measure | Time frame |
|---|---|
| Height velocity;Height standard deviation scores;Bone age;IGF-1 standard deviation scores; | — |
Countries
China
Contacts
Public ContactLiyang Liang
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Outcome results
None listed