Effect of high salt diet on brain function based on functional magnetic resonance imaging

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200064377

Enrollment

Unknown

Registered

2022-10-05

Start date

2022-11-01

Completion date

Unknown

Last updated

2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cognitive decline

Interventions

Intervention group:High salt diet

Eligibility

Sex/Gender

All

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1. There were 30 healthy adults aged 18~45, 15 males and 15 females; 2. All female participants ensured that they did not use oral hormonal contraceptives and had no intention of new pregnancy during the intervention; 3. Sign a dated written informed consent.

Exclusion criteria

Exclusion criteria: 1. Suffering from stomach pain, bloating, constipation, diarrhea, cardiovascular disease (stroke, heart failure, coronary heart disease, and peripheral artery disease), blood disease, cancer, diabetes, hypertension, renal insufficiency (EGFR 30 kg/m^2), claustrophobia, epilepsy, high risk of depression (cesd-10 score >= 10), or depression, and history of nicotine product use; 2. Current pregnancy, or suspected metal foreign bodies in the eyeball and beside the great vessels after the installation of cardiac pacemakers, internal fixation metal implants, automatic cardioverter defibrillators, functional nerve stimulators, cardiac stents, artificial heart valves, metal clips after aneurysm surgery; 3. Those who do not agree to sign the informed consent of patients; 4. Those who have taken antibiotics, or non-steroidal anti-inflammatory drugs within 3 months, or have the habit of eating probiotic products and change the type of probiotics they eat within the recent 1 month; 5. Addicts to cigarettes, alcohol, and drugs; 6. The basic salt intake is more than 8 g / day; 7. People who are allergic to lactulose and gelatin or have dietary restrictions on lactose and gelatin.

Design outcomes

Primary

Measure	Time frame
FMRI analysis results;	—

Secondary

Measure	Time frame
AVLT-H score;Serum level of LPS binding protein;Serum level of S100ß;Composition of 16SrRNA fecal flora;Metabonomics of serum;Metabonomics of feces;24-hour urinary sodium;Lactulose recovery;mannitol recovery;lactulose / mannitol ratio;	—

Countries

China

Contacts

Public ContactZhou Liu

Affiliated Hospital of Guangdong Medical University

liuzhou@gdmu.edu.cn+86 13543558835

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026