olfactory dysfunction associated with chronic sinusitis
Conditions
Interventions
Test group (stent implantation side):implanting bioabsorbable sinus steroid eluting stent into olfactory cleft
control group(Opposite to the stent placement side):no stent
Sponsors
the Second People's Hospital of Shenzhen
Eligibility
Sex/Gender
All
Age
21 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. All patients with sinusitis were clinically diagnosed in accordance with the European opinion on the diagnosis and treatment of sinusitis and nasal polyps 2020 crswnp diagnostic guidelines, and were intended for initial surgical treatment; 2. The diagnosis of olfactory dysfunction in all patients should comply with the European opinion on the diagnosis and treatment of sinusitis and nasal polyps 2020 diagnostic guidelines for chronic sinusitis-related olfactory dysfunction; 3. All patients received t&t standard olfactory test at admission, with scores of 3 or more and equal, that is, all patients had olfactory disorders to varying degrees; Polyps were found in bilateral olfactory cleft by endoscopic examination before operation; 4. 55 years old >= age >= 21 years old; 5. Volunteer to participate in this study and sign the informed consent for the placement of drug stents in nasal sinuses in olfactory fissure; 6. The subjects had a poor effect after pre-standardized drug treatment (> 3 months), and had a clear intention of surgery.
Exclusion criteria
Exclusion criteria: 1. The subjects had known allergic reactions or contraindications to the fully degradable nasal sinus drug stent and its degradation products (mometasone furoate, L-polylactic acid, racemic polylactic acid, lactide, lactic acid); 2. Need long-term oral hormone drugs; Patients who are receiving immunosuppressive therapy or are known to have immunosuppressive or autoimmune diseases; 3. Patients with severe diabetes or other serious diseases that affect the operation; 4. Suffering from acute inflammation and tumor of the nasal cavity and paranasal sinus; Patients with intracranial tumors; 5. There are contraindications related to endoscopic surgery; 6. Those who are mentally retarded and cannot cooperate to complete various scores.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Nasal olfactory t&t test score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Modified nasal sinus CT olfactory fissure score;Olfactory fissure score of Lund Kennedy nasal endoscopy; | — |
Countries
China
Contacts
Public ContactQingguo Meng
Outcome results
None listed