centrally mediated abdominal pain syndrome(CAPS)
Conditions
Interventions
CAPS group:Oral duloxetine
healthy control group:none
Sponsors
Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: CAPS group: aged 18-85 years old; meet Rome IV CAPS diagnostic criteria Healthy control group: 18-85 years old; no abdominal pain and other digestive system symptoms; no organic lesions found under gastroscopy and colonoscopy in the past 6 months
Exclusion criteria
Exclusion criteria: Subjects meeting any of the following criteria will be excluded from this study: 1. Patients with organic diseases and important organ diseases; 2. Those who have contraindications to the use of drugs in this study; 3. Those who are taking other antidepressants; 4. Have mental retardation, cognitive dysfunction or mental history, epilepsy; 5. Pregnant and lactating women; 6. Meet the diagnostic criteria of anxiety and depression in the diagnostic and Statistical Manual of mental diseases (DSM-IV), and be diagnosed as anxiety and depression; 7. Hamilton Anxiety Scale (HAMA) score >= 14, Hamilton Depression Scale (HAMD) score >= 18; 8. Blood pressure >140/90mmhg; 9. Those who have recently received abdominal surgery; 10. Family history of ulcerative colitis, Crohn's disease, celiac disease and colon cancer; 11. People with angle closure glaucoma, uncontrolled thyroid diseases, tumors, etc; 12. Patients who are unwilling or unable to follow the protocol to continue the study, or who are unable to cooperate with the follow-up; 13. The researcher believes that it is not suitable to participate in this experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differential expression of miRNAs between CAPS group and healthy control group;The changes in abdominal pain scores before and after duloxetine treatment in patients with CAPS and their relationships with changes in miRNA; | — |
Secondary
| Measure | Time frame |
|---|---|
| The changes in depression, anxiety, sleep quality and quality of life scores before and after duloxetine treatment in patients with CAPS and their relationship with changes in miRNA; | — |
Countries
China
Contacts
Public ContactTang Yuming
Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital
Outcome results
None listed