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Effect of Recombinant Luteinizing Hormone supplementation on ART outcome in low prognosis patients (POSEIDON group I) in second IVF cycles during early or mid-late follicular phase with LH/LHCGR gene polymorphism: a single-center, prospective, cohort study

Effect of Recombinant Luteinizing Hormone supplementation on ART outcome in low prognosis patients (POSEIDON group I) in second IVF cycles during early or mid-late follicular phase with LH/LHCGR gene polymorphism: a single-center, prospective, cohort study

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200064369
Enrollment
Unknown
Registered
2022-10-05
Start date
2022-10-01
Completion date
Unknown
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility

Interventions

rLH 75 IU/d from day-1:rLH 75 IU/d from day-1
rLH 75 IU/day from day-6:rLH 75 IU/day from day-6

Sponsors

West China Second Hospital, Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 35 Years

Inclusion criteria

Inclusion criteria: Participants are eligible to be included in the study only if all the following criteria apply: 1. POSEIDON group I who underwent the second cycle following GnRH antagonist protocol POSEIDON group I: Patients= 5, AMH >= 1.2 ng/mL) and with an unexpected poor or suboptimal ovarian response with the retrieval of zero to nine oocytes 2. Age 20-35 years old in the second IVF cycle; 3. 18<BMI<26 kg/m^2; 4. GnRH antagonist protocol with rFSH stimulation in the first cycle; 5. Without ART contradictions.

Exclusion criteria

Exclusion criteria: Participants are excluded from the study if any of the following criteria apply: 1. Patients who required starting dose or dose adjustments >300 IU in the first cycle; patients who employed average dose <150IU/d during stimulation with rFSH in their previous cycle; 2. Uterine disorders (intrauterine adhesions, uterine fibroids, endometritis, etc.); 3. Patients with endocrine and metabolic disease diseases (diabetes mellitus, hypogonadotropic amenorrhea, genital system tumors, hyperprolactinemia, chromosomal disorders, etc.); 4. Patients with other pelvic and abdominal diseases (III-IV endometriosis, inflammatory, autoimmune, etc.).

Design outcomes

Primary

MeasureTime frame
Retrieved oocytes number;

Countries

China

Contacts

Public ContactTian Tang

West China Second Hospital, Sichuan University

tangsisley@163.com+86 18628157383

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026