total knee arthroplasty
Conditions
Interventions
High dose group:First tranexamic acid 60 mg/kg
Conventional dose group:First tranexamic acid 20 mg/kg
Sponsors
Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine
Eligibility
Sex/Gender
All
Age
55 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age 55-80 years old, gender is not limited; 2. Diagnosed with osteoarthritis, hospitalization option in general anesthesia under unilateral knee replacement surgery cases, no contraindications to surgery, agree to participate in this test; 3. The American Association of Anesthesiologists (ASA) is graded as Grade I or II.
Exclusion criteria
Exclusion criteria: 1. Those who have a history of deep vein thrombosis, arterial thrombosis, cardiovascular and cerebrovascular thrombosis or infarction, and pulmonary embolism in the past 6 months; 2. Color Doppler ultrasound examination of both lower extremities before surgery, showing thrombosis of the popliteal vein and its proximal vein, or obvious stenosis of the atherosclerosis of the lower limbs; 3. Allergic constitution: allergic to dextran, tranexamic acid, threxin and anticoagulants; 4. Coagulation dysfunction; 5. Patients who cannot stop using double antiplatelet drugs: such as those who wear pacemakers, have a history of cardiac bypass surgery or arterial stenting, etc.; 6. People with ischemic heart disease or cardiac insufficiency; 7. Those who have malignant tumors and are in the treatment period; 8. ASA grade IV or above; 9. After treatment of patients with hypertension, the systolic blood pressure > 160mmHg or the diastolic > 100mmHg; 10. Preoperative liver and kidney insufficiency; 11. Women planning to become pregnant, pregnant and lactating; 12. Participate in other clinical studies at the same time 3 months before surgery or during the study period; 13.Patients with mental disorders, non-cooperation, or who are considered unsuitable to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood loss; | — |
Secondary
| Measure | Time frame |
|---|---|
| Coagulation function;Incidence of arteriovenous thrombosis in both lower extremities;Incision healing condition;Probability of blood transfusion;Blood transfusion volume;Pain score;AKS knee score;Joint range of motion score; | — |
Countries
China
Contacts
Public ContactZhong Sheng
Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine
Outcome results
None listed