Depression after radical mastectomy in perimenopausal women
Conditions
Interventions
Esketamine group:Esketamine
Sponsors
First Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
Female
Age
45 Years to 60 Years
Inclusion criteria
Inclusion criteria: Voluntary to participate in this experiment, aged 45-60 years old; ASA class I-III female patients who plan to undergo elective unilateral breast cancer radical surgery under general anesthesia.
Exclusion criteria
Exclusion criteria: (1) Unplanned or emergency surgery; (2) EF < 30% or severe pulmonary disease (type I or type II respiratory failure); (3) Severe liver and kidney disease (Child-Pugh grade C, requiring renal replacement therapy); (4) Mental illness, abnormal cognitive function, long-term use of antipsychotic drugs or drug addicts; (5) Allergies or contraindications to the drugs used in the study (6) Illiteracy or inability to understand the scale in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of depression; | — |
Secondary
| Measure | Time frame |
|---|---|
| Depression score;Incidence of depression;Anxiety incidence and score;VAS pain scores (at rest, on coughing);PONV;Quality of recovery;Length of postoperative hospital stay; | — |
Countries
China
Contacts
Public ContactKe Peng
First Affiliated Hospital of Soochow University
Outcome results
None listed