cancer pain
Conditions
Interventions
intervention group:Infusion of esketamine
Conrol group:Conventional opioid therapy+normal saline
Sponsors
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with cancer pain who take at least 60 mg of morphine or 30 mg of oxycodone or other equivalent opioids per day for at least one week, or use two or more opioids in combination, or the doses of opioids used in two or more ways converted >= equivalent Oral morphine 60mg, and continuous use for at least 1 week in patients; 2. VAS score >= 6 points or burst pain >= 3 times/24h; 3. Age >= 18 years old and <= 70 years old, gender is not limited; 4. Understand and agree to participate in this study and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. A history of opioid abuse and alcohol abuse; 2. Patients with severe cardiovascular disease, hypertension, severe liver and kidney damage; 3. Patients with impaired consciousness or with severe mental and nervous system diseases; 4. Increased intracranial pressure or intraocular pressure; 5. Pregnant or lactating women.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| patient quality of life score;(S)-ketamine and its metabolite (S)-norketamine plasma concentrations; | — |
Primary
| Measure | Time frame |
|---|---|
| pain score;Opioid Dosage; | — |
Countries
China
Contacts
Public ContactLi Caixia
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine
Outcome results
None listed